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Local professional idiot rants about ...stuff...

Biden sucks at leading.
Forced to acknowledge that Israel I have the right to defend itself against the Hummock attacks over the past few weeks
Cannot get anyone back to the table for the Iran nuclear deal, dad idea in the first place
Pipeline Cyber attack
Has no message Beyond I'm not orange man
Personally Mean Tweets equal cheaper gas? Yes!

Vax?
What is an RNAvaccine?
What is traditional vaccine
Should RNA vaccines be classified as vaccine?

Click to enlarge
By now, we’re all familiar with the image of coronavirus. The spikey blob peppers news websites, looms behind reporters during bulletins and frequently punctuates your Twitter doom-scrolling. More recently, the news accompanying this image has taken a positive turn, with promising results from the COVID-19 vaccine trials. It’s the iconic spikes of the coronavirus spikey blob that are a key part of how these vaccines work.

Let’s backtrack a little and start with the broader COVID-19 vaccine picture. As of 1 December 2020, thirteen vaccines have reached the final stage of testing: where they are being given to thousands of people to test if they protect against the SARS-CoV-2 virus. Though the end goal is the same, these vaccines vary in the ways in which they try to trigger our immune system to recognise the virus. All of these ways have been used in licensed vaccines for other diseases previously – except RNA vaccines.

Two vaccines which have recently reported results are RNA vaccines produced by Moderna and by Pfizer & BioNTech. Other RNA vaccines in the pipeline include those produced by CureVac, Imperial College London, and Arcturus. Results so far have been overwhelmingly positive. At the start of December, Pifzer’s vaccine became the first RNA vaccine licensed for widespread use in the UK.

Other types of vaccines often use inactive or weakened forms of a virus to trigger an immune response. But RNA vaccines use a virus’s own genetic code against it. RNA stands for ribonucleic acid; you’re probably more familiar with DNA, the molecule which makes up human genetic code. RNA makes up the virus genetic code, which contains instructions for the proteins the virus needs to make.

Early in the pandemic, Chinese scientists were able to isolate samples of the SARS-CoV-2 virus and determine its genetic code. This catalogued all the instructions the virus uses to make its various proteins. These include the spikes of the coronavirus ‘spikey blob’: its spike proteins. The spike proteins are the structures that the virus uses to penetrate cells and kick off an infection.

Spike proteins are also key to how RNA vaccines work. Scientists are able to make synthetic RNA in a lab which codes for the virus spike protein. Using this synthetic RNA, we can hijack the processes which create proteins in our own cells.

The genetic material in our bodies is DNA. In the nucleus of our cells, an enzyme splits apart the two strands that form DNA to form single-stranded messenger RNA. The mRNA moves out of the nucleus to our cells’ cytoplasm. Here, molecules called ribosomes translate the RNA’s code into proteins. In short, the ribosome is like a protein-making factory, and the mRNA created from our DNA is the blueprint for the proteins it makes.

RNA vaccines take advantage of the fact that our ribosome factory doesn’t care where a blueprint comes from. So if we can smuggle a new blueprint for the virus spike protein into this factory, the ribosome will assemble the protein without question. Once it’s manufactured, the spike protein sticks to the surface of our cells and triggers a response from our immune system.

Smuggling the blueprint into our cells isn’t straightforward. If we simply inject the RNA on its own, enzymes in our bodies would break it down before it could enter our cells. For this reason, it’s encapsulated in lipid nanoparticles: tiny fat droplets around one billionth of a metre in diameter. These nanoparticles shield the RNA, stopping it from breaking down, and help it get taken up by our cells.

Amongst the COVID-19 vaccines, there are two types of RNA vaccine. These are messenger RNA (mRNA) vaccines, like those produced by Moderna and Pfizer/BioNTech, and self-amplifying RNA (saRNA) vaccines, like that developed by Imperial College London.

The structures of mRNA and saRNA used in the vaccines are very similar but have one key difference. Both contain the region of the RNA which codes for the virus spike protein. Both also contain a cap, which stops the RNA breaking down and helps start protein synthesis in our cells, and a tail which helps stabilise the RNA. Unlike mRNA, saRNA also contains the code for a virus enzyme. This enzyme helps create multiple copies of the virus RNA once it’s in our cells, leading to quicker protein production.

As saRNA produces more copies of itself once it’s in a cell, it means tha

Fatman InParadise and The Great American Audit.

My BitChute channel because Facebook would not let me post my videos for whatever reason

https://www.bitchute.com/channel/89tLFvSzlkOW/

Here's my telegraph Channel call the peanut gallery where everyone is welcome to the sky's the Great American audit and who was willing to take part in it

https://t.me/joinchat/TLsRY2JLe5P4FHRd

A brief description on how we can get our voices heard.

Me leaving the rally turned violent demonstration.

Me stating my intention to get out if there because of what was going on and the likelihood of more teargas

None

Fatman birthday is coming you once again from Paradise
This house #OpenWaianae and #ReligiosFreedom

They showed up at a Grassroots Trump rally here in one of the bluest States of the Union.
Did interviews with a couple of individuals who were there expressing the different reasons why they support Trump and the enthusiasm was quite contagious dot-dot-dot more than any coronavirus that I know of.

#ClownLivesMatter #CLM #FatmanInParadise #OpenHawaii #Hawaii4Trump #MAGA2020 #KAG2020 #Obamagate #LetFreedomRing #Liberty4All #DemocratsForTrump #Democrats4Trump

papal.me/fatmansinparadise
https://shop.spreadshirt.com/fatmans-shop-in-paradise-/
I love BAT coin....

well...it's in the title.
#ClownLivesMatter #LetFreedomRing #CopyrightThis #OpenHawaii #FatmanInParadise #CLM #Thanks4TrumpJoe #DIMocRATS

The fat man in Paradise once again making a nuisance of himself in front of the Carew building on South Beretania Street in Honolulu Hawaii.
#clownlivesmatter #igechucks #kimchucks