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The topic of Human Growth Hormone is a complex one. There is quite a rift between the average person's perception of HGH and its reality.
The goal of this article is to clear the air about Human Growth Hormone and help you understand the role of HGH and the targets of Human Growth Hormone Therapy more precisely.
What is Human Growth Hormone?
First things first: Human Growth Hormone is one of the many important hormones that the human body produces to sustain and protect its normal and healthy function.
In a way, HGH has a simple purpose: it facilitates cellular metabolism. Though its objective is simple, its effect is complex and widespread.
During human development, Growth Hormone is responsible for helping us grow both larger and taller. Without the influence of HGH, human development would not be possible.
Elevated HGH Levels are responsible both for rapid prenatal development as well as the growth spurt associated with puberty. At the cessation of puberty, HGH levels fall to a healthy adult plateau, which no longer encourages growth, but does protect and facilitate peak, optimal function.
How Does the Body Produce Human Growth Hormone?
HGH is a member of what is known as the Hypothalamic-Pituitary-Liver Axis. An axis represents an interplay of hormones that act with one another. HGH is released by tiny cells in the pituitary gland known as Somatotrophs.
The production of Human Growth Hormone is mediated by a precursor hormone (or secretagogue) called Growth Hormone-Releasing Hormone, which activates the Somatotrophs.
GH-RH is released by the hypothalamus as a result of stimuli it receives from the body, including circulating levels of HGH and IGF-1 in the bloodstream.
The hypothalamus can also down-regulate Growth Hormone Production by releasing Somatostatins, which block Somatotroph activity.
When Human Growth Hormone is released, it circulates through the bloodstream and acts on some targets throughout the body, but most HGH travels to the liver, where it is converted into Insulin-Like Growth Factor-1.
It is through the activity of IGF-1 that Human Growth Hormone provides the bulk of its benefits, as it interacts with cells in practically every system of the human body.
