NAC vs. Glutathione Supplements

NAC vs. Glutathione supplements - NAC works to raise GSH levels far better than oral glutathione supplements primarily because reduced glutathione is an endogenous antioxidant that is best produced by the body from raw materials: the amino acids L-cysteine, glutamic acid, and glycine. 2 of the 3, L-cysteine and glycine, are rate-limiting nutrients for GSH production. NAC, or N-acetyl-L-cysteine, provides your body with valuable L-cysteine to increase glutathione production. Glycine is also valuable in this equation. The body synthesizes GSH in a two-part process: 1) L-cysteine links with glutamic acid by means of glutamate cysteine ligase, resulting in gamma-glutamylcysteine (GGC); 2) glycine is attached by means of glutathione synthase. Research has shown that GGC converts to 5-L-oxoproline and is excreted in the urine when there is not enough glycine available to complete the transition to GSH.

Links:
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/

Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/

Disclaimer:
All of the information on this channel is published in good faith and for educational purposes only. Primal Brain Hacks does not make any guarantee as to the completeness, reliability, or accuracy of this information.
The information provided on this channel is not intended to be nor does it constitute professional medical advice. Do not rely on this information as a substitute for professional medical advice. The use of any information contained on this channel is strictly at your own risk. Primal Brain Hacks will not be liable for any losses and/or damages in connection with the use of this channel.