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How Does Tadalafil Treat Benign Prostatic Hyperplasia?
Although Tadalafil is FDA approved for the treatment of Benign Prostatic Hyperplasia (when it occurs in combination with Erectile Dysfunction), the mechanisms by which Tadalafil achieves this purpose is not fully understood.
There are three primary hypotheses:
The bladder and prostate both respond to signals of relaxation, as produced by cyclic guanosine monophosphate (cGMP). By relaxing the muscles of the bladder and prostate, it makes it easier to pass urine.
Related to the previous hypothesis, it is also believed that Tadalafil allows blood to circulate through the prostate and bladder more effectively, which improves urinary capacity.
The third hypothesis is that PDE5 inhibitors improve the ability for central nervous system signaling to reach the bladder and prostate.
Side Effects of Tadalafil
Tadalafil is a popularly prescribed medication all throughout the United States and the globe. It has been thoroughly researched, with clinical trials accumulating 15,000 patients. As of today, more than 8 million men have used Tadalafil for Erectile Dysfunction and its related uses.
As with any medication, Tadalafil (Cialis) is not free of risk and as with any prescription drug, should be taken under the supervision of a medical physician. There are some minor side effects that patients sometimes experience that is associated with the use of Tadalafil, including a runny nose, flushing, muscle pain, back pain, acid reflux, burping, indigestion, stomach discomfort, and headache.
For the most part, the symptoms listed above are the result of either the effects of PDE5 inhibitors on non-target muscles or the result of the medication reacting with stomach acids. The drug is coated to promote absorption and allows the medication to pass through the stomach to the intestines before fully activating.
The aches and pains associated with the use of Tadalafil generally occur within twelve hours to one day after the treatment is taken, and can last up to two days, fading as the medication is metabolized and its effectiveness dissipates.
Tadalafil has also been loosely linked with vision issues when taken, a result of a condition known as Nonarteritic Anterior Ischemic Optic Neuropathy (NAION). Medical examination has shown that this issue is likely only an issue for patients that display symptoms which put them at risk for the condition, including being over the age of fifty while also being a smoker or suffering from hyperlipidemia, coronary artery disease, hypertension, glaucoma, or diabetes.
This condition is serious, but incredibly rare, affecting less than one in every million patients. It is so rare among patients that use PDE5 Inhibitors that there is no way to measure correlation with any certainty, and it may just be coincidence.
In a small subset of patients, hearing loss occurred while taking Tadalafil. This risk is quite low, but notable enough that the FDA requires Tadalafil and its related medications to have the risk clearly noted on the bottle and in advertisements.
Tadalafil Drug interactions
Tadalafil is safe for the majority of patients, but there are some patients that should not take Tadalafil. Tadalafil does have a suppressive effect on blood pressure which isn't generally a major issue on its own, but when combined with other medications or recreational drugs which drop blood pressure, such as Nitrate medications and Organic Nitrates, it should not be used within two days of taking Tadalafil. Taking these drugs simultaneously can lead to dangerous hypotension, which can drop blood pressure so low that it can put your life at risk.
Organic nitrates are often used as a means to treat angina, and should never be used within two days of using Tadalafil. These patients will likely benefit from the PDE5 Inhibitors with a shorter half-life so that they reduce the risk of experiencing angina without the ability to treat the condition effectively.
Because of Tadalafil's effect on blood pressure, if the patient requires any medical attention, it is vital that the physician or other medical professional be notified immediately.
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