https://www.testosterone.me/tadalafil-cialis-guide
What is Tadalafil?
Tadalafil belongs to a class of medications known as phosphodiesterase type 5 inhibitors, or simply PDE5s. Sildenafil belongs to this pharmaceutical class as well. Most patients know these two drugs as Cialis (Tadalafil) and Viagra (Sildenafil). Tadalafil is primarily used as an Erectile Dysfunction medication, but can also be used to treat Pulmonary Arterial Hypertension, a condition in which the arteries which carry blood from the heart to the lungs are excessively constricted, causing blood to flow through the region at an abnormally high pressure.
When Tadalafil is prescribed as an Erectile Dysfunction treatment is it usually referred to as Cialis, but it is marketed as Adcirca as a hypertension medication. As of 2011, Tadalafil earned FDA approval for the treatment of a condition known as Benign Prostatic Hyperplasia, a condition in which the prostate grows larger, but not due to cancer or malignancy. In this case, Tadalafil is specifically prescribed to patients that simultaneously experience both Erectile Dysfunction and Benign Prostatic Hyperplasia simultaneously.
Tadalafil was initially invented by a small biotech company which was based in Washington, known as Icos Corporation, in partnership with Glaxo Wellcome. Eventually, Icos Corporation entered a collaboration with Eli Lilly and expanded marketing and development with their new associates.
What Does Tadalafil Look Like?
Tadalafil is available in pills of four dosages: 2.5 Milligram, 5 Milligram, 10 Milligram, and 20 Milligram. The pills are teardrop shaped, coated with film, and yellow. For the treatment of Pulmonary Arterial Hyperplasia, the prescription is generally 40 milligrams of Tadalafil daily, in the form of 2 of the largest pills.
In India, Tadalafil is produced and distributed under the brand name Tadacip and is available as 10 milligram and 20-milligram pills.
Three PDE-5 Inhibitors Available in America
There are three primary Erectile Dysfunction medications available on the market—Levitra (Vardenafil), Viagra (Sildenafil), and Cialis (Tadalafil). Cialis was the last of these drugs to be approved by the Food and Drug Administration, but they were all developed in the same general time frame. Viagra reached FDA approval in spring of 1998, Levitra in summer of 2003, and Cialis in fall of 2003.
All three of these medications are designed to be taken in the hours preceding sexual activity, in order to stimulate full sexual function. Out of the three, Cialis is unique, because it can be prescribed daily, whereas the others are only indicated for use as as-needed sexual aids.
The use of Tadalafil for Pulmonary Arterial Hypertension is under the purview of United Therapeutics in America, as Eli Lilly sold their rights to market and distribute Tadalafil for such purposes.
What is a PDE5 Inhibitor?
PDE5 Inhibitors are medications that are designed to inhibit the action of the PDE5 Enzyme, which can suppress the ability of the male penis to reach an erection. There are muscles in the penis which inhibit blood flow when exposed to PDE5, and when a healthy patient experiences arousal, PDE5 is suppressed, which loosens up the hold the muscles of the penis have on the circulatory structures of the penis, which leads to erection. All three of the common Erectile Dysfunction medications work via this same mechanism.
What is the Difference between Viagra and Cialis?
Both of these medications are remarkably similar, and produce their benefits via the same mechanisms. The major benefit of Cialis over Viagra is that Cialis remains active in circulation for a longer period of time. Cialis has a half-life of over 17 hours, and provides ED benefits for up to a day and a half after the pill is taken. Viagra, on the other hand, has a half-life of less than five hours.
What is the Difference between Levitra and Cialis?
Like Viagra, Levitra also has a half-life of less than five hours, which means that a single pill of Cialis provides a longer window for sexual activity than both of its competitors. For this reason, Cialis is frequently marketed as a medication which provides men with the opportunity to facilitate romantic activity on their own time, rather than the shorter window provided by the other two treatments.
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