Hypopituitarism is a condition defined by a lack of hormone production by the pituitary gland. The pituitary gland produces a multitude of essential hormones which are necessary for the body to function normally.
Hypopituitarism can be related to the production of a single hormone, such as Human Growth Hormone, or multiple hormones associated with the Pituitary gland.
There are two forms of Hypopituitarism: Primary Hypopituitarism and Secondary Hypopituitarism. Primary Hypopituitarism is the result in issues related to the physiological function of the pituitary gland itself which suppress the body's ability to produce Pituitary Hormones.
For example, HGH Deficiency is sometimes the result of tumors on or around the pituitary gland which inhibit the ability of cellular organs known as Somatotrophs from producing Human Growth Hormone.
Secondary Hypopituitarism is the other form of Hypopituitarism and is the most common. Secondary Hypopituitarism refers to conditions which inhibit the ability of the Pituitary Gland to perform its normal and healthy function, resulting from issues upstream from the Hypothalamus.
The Hypothalamus regulates most hormone functions in the human body and is the primary root cause of both Age-Related HGH Deficiency and Low-T.
In the case of Age-Related Human Growth Hormone Deficiency, the Hypothalamus sends smaller and smaller signals for HGH over time, which can eventually lead to symptoms of Deficiency.
Age-Related Testosterone Deficiency (also known as Andropause), is the result of declining levels of Gonadotropin-Releasing Hormone produced by the Hypothalamus, which leads to inhibited production of Luteinizing Hormone and Follicle Stimulating Hormone by the Pituitary, which impacts the production of both Testosterone and Sperm.
Testosterone Deficiency is primarily caused by the overactivity of Estrogen Receptors on the Hypothalamus which inhibit Testosterone Precursor signaling, whereas Growth Hormone Deficiency is more complicated, although Somatostatins do seem to play a role.