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Other Medical Uses of Tamoxifen, including Off-Label Use of Tamoxifen
Tamoxifen Treatment for McCune-Albright Syndrome
McCune-Albright Syndrome is a genetic condition which impacts the bone growth and pigmentation in both boys and girls and is most notable because it encourages early puberty.
Tamoxifen can be used to prevent the bones from maturing too quickly, which causes the pediatric patient not to grow as tall as usual.
There are some potential issues and complications, however.
Research published in 2008 showed that Tamoxifen might produce unwanted side-effects, such as reduced HGH production and changes in bone maturation which may lead to this form of treatment to be limited in the future.
Tamoxifen Treatment for Fertility
Tamoxifen has been effectively utilized to promote fertility in women suffering from conditions which limit their ability to ovulate.
Because of its positive impact on endometrial function, Tamoxifen helps stimulate a regular menstrual cycle when taken from days three to seven of the cycle.
Tamoxifen Therapy can also promote fertility in women that have experienced breast cancer in the past. Tamoxifen is also considered a viable alternative to Clomiphene Citrate and is often used in patients that do not respond to Clomiphene Citrate Fertility Treatment.
Tamoxifen Gynecomastia Treatment
Because Tamoxifen is highly effective at limiting the development of breast tissue, it is often used as an alternative to aromatase inhibitors such as Clomiphene Citrate in male patients experiencing gynecomastia.
It is also sometimes used by individuals that abuse steroids for the same reason. Often, Tamoxifen is used before symptoms appear but are also commonly prescribed and/or used when preliminary symptoms of gynecomastia appear, including nipple sensitivity and soreness.
Tamoxifen and Bipolar Disorder
Tamoxifen has been used to some success as a means of alleviating the severity of manic episodes among patients suffering from bipolar disorder.
In addition to its effects upon Estrogen activity, Tamoxifen also mitigates the activity of protein kinase C (PKC) in the brain.
There is evidence that manic activity from bipolar disorder is at least partially caused by abnormally high levels of PKC activity in the brain.
Tamoxifen, Angiogenesis, and the Navy Protocol
When a person develops cancer, cancer cells send out signals which promote the development of blood vessels which feed nutrients to the cancer cells, encouraging their growth.
A therapeutic cocktail of Tamoxifen, Doxycycline, and Celecoxib was used in a canine cancer patient named Navy, hence the name. Further research has shown that Tamoxifen treatment provided alone can limit the angiogenic activity associated with cancer in animal research.
In the future, Tamoxifen may be utilized as a means to treat cancer in human patients. The Navy Protocol is still used in veterinary medicine today.
Tamoxifen and Riedel's Thyroiditis
Riedel's Thyroiditis is an inflammatory condition which affects the connective tissue of the thyroid capsule.
Over time, this condition afflicts the muscles of the neck and results in the compression of the trachea. Tamoxifen Therapy is often used in combination with surgery to treat the symptoms.
