JourneyOfAdam
9 countries ban the AstraZeneca vaccine.
Covid-19 vaccination: What’s the evidence for extending the dosing interval?
BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.n18 (Published 06 January 2021)
Cite this as: BMJ 2021;372:n18
Read our latest coverage of the coronavirus outbreak
Opinion
Covid-19 vaccines: to delay or not to delay second doses
Opinion
How do you take your vaccine—one lump or two?
Article
Metrics
Responses
Gareth Iacobucci, Elisabeth Mahase
Author affiliations
On 30 December the four UK chief medical officers announced that the second doses of the covid vaccines should be given towards the end of 12 weeks rather than in the previously recommended 3-4 weeks. Gareth Iacobucci and Elisabeth Mahase look at the questions this has raised
Why has the government taken the step to delay the second dose?
In a letter sent to healthcare staff on 30 December NHS England said the decision had been taken to prioritise giving the first doses of vaccine (whether the Pfizer and BioNTech one or that of Oxford University and AstraZeneca) to as many people as possible on the priority list to “protect the greatest number of at-risk people overall in the shortest possible time.”1 Delaying the second dose meant that the prioritisation process “will have the greatest impact on reducing mortality, severe disease and hospitalisations and in protecting the NHS and equivalent health services,” it said.
Why was this decision taken?
In a letter to the profession sent on 31 December laying out the “scientific and public health rationale” for the change to the dosing schedule,2 the chief medical officers said that vaccine shortages were a major reason for the shift in approach. “We have to ensure that we maximise the number of eligible people who receive the vaccine. Currently the main barrier to this is vaccine availability, a global issue, and this will remain the case for several months and, importantly, through the critical winter period. The availability of the AZ [AstraZeneca] vaccine reduces, but does not remove, this major problem. Vaccine shortage is a reality that cannot be wished away.”
What’s the evidence for changing the schedule?
There isn’t much for the Pfizer-BioNTech vaccine, as trials did not compare different dose spacing or compare one with two doses. The trials of the Oxford-AstraZeneca vaccine did include different spacing between doses, finding that a longer gap (two to three months) led to a greater immune response, but the overall participant numbers were small. In the UK study 59% (1407 of 2377) of the participants who had two standard doses received the second dose between nine and 12 weeks after the first. In the Brazil study only 18.6% (384 of 2063) received a second dose between nine and 12 weeks after the first.3 The combined trial results, published in the Lancet,4 found that vaccine efficacy 14 days after a second dose was higher in the group that had more than six weeks between the two doses (65.4%) than in the group that had less than six weeks between doses (53.4%).
Link
https://www.bmj.com/content/372/bmj.n18
AstraZeneca vaccine apparently hardly effective in seniors,” reported the German economic newspaper Handelsblatt on Monday 25 January. “Setback for vaccine” ran as its top story in print the next day,1 subtitled, “The AstraZeneca vaccine apparently has an effectiveness of only 8% in the elderly. The government’s vaccination strategy is shaky.”
-------------------------------------------
Who were they injecting first? Nursing home elderly, and in the article they say we're telling derly Not to get the vaccine, when that was in reality their main target. They say the opposite of what actions they carry out. Actions are Always Louder than Words. And vaccine company should never be trusted because their words and actions are what I call LIES and criminal ACTION.
If you need proof, please watch my movies. You can start with FOIA request-CDCs internal unpublished studies. See what they actually secretly have tested and not released to the public, and is forced on every child in America. You come to an alternate conclusion than me.
Thanks for Watching
