CBD (cannabinoid) oil

Cannabis is an area of growing interest in the treatment of specific conditions. Importantly only specific conditions. The best studied of which is children’s epilepsy. There is evidence that it can help in reducing the frequency and severity of seizures.

CBD oil is a related product that has found use and registration for the same conditions. It is made from several formulations derived from either cannabis or hemp. One option is an only CBD solution that has no psychoactive component that will cause euphoria and relaxation.

Others use a mixture of CBD and THC. THC is one of the active components in cannabis. This causes the narcotic effect. Both possible formulations are used in both prescription and over the counter products.

The different formulations lead to very different products which can have extremely different effects. This is reflected in the available literature which does not appear to show a large body of evidence to support the use for many conditions.

When it comes to epilepsy there is some evidence that CBD is an effective treatment. Like cannabis it can reduce the severity and frequency of seizures.

There are a few limited examples of it working for a lot of different conditions but these are based on poor quality or limited studies. This is the important point. CBD use for others conditions is based on poor research that may yet be elucidated or not.

Relevant links:

Galenic Preparations of Therapeutic Cannabis sativa Differ in Cannabinoids Concentration: A Quantitative Analysis of Variability and Possible Clinical Implications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344428/

Cannabis for the treatment of Crohn's disease
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012853.pub2/full

A systematic review of cannabidiol dosing in clinical populations
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.14038

An Update of Current Cannabis-Based Pharmaceuticals in Pain Medicine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514017/

Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473697/

The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212868/

The Modulating Role of Sex and Anabolic-Androgenic Steroid Hormones in Cannabinoid Sensitivity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212868/

Purified Cannabidiol for Treatment of Refractory Epilepsies in Pediatric Patients with Developmental and Epileptic Encephalopathy
https://link.springer.com/article/10.1007%2Fs40272-019-00341-x

Pharmacokinetics and tolerability of oral cannabis preparations in patients with medication overuse headache (MOH)—a pilot study
https://link.springer.com/article/10.1007%2Fs00228-018-2516-3

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)
https://www.sciencedirect.com/science/article/abs/pii/S0731708517322367?via%3Dihub

Cannabis oil for epilepsy – what you need to know
https://theconversation.com/cannabis-oil-for-epilepsy-what-you-need-to-know-98499

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test.
https://www.ncbi.nlm.nih.gov/pubmed/30328956

Cannabidiol: an overview of some pharmacological aspects.
https://www.ncbi.nlm.nih.gov/pubmed/12412831

Marijuana or Hemp: FDA Says Beware Of CBD For These Reasons
https://www.forbes.com/sites/mikeadams/2019/07/07/fda-says-beware-of-cbd-for-these-reasons/#2663c10b300d

Purified Cannabidiol for Treatment of Refractory Epilepsies in Pediatric Patients with Developmental and Epileptic Encephalopathy
https://link.springer.com/article/10.1007%2Fs40272-019-00341-x

The effects of cannabinoids on the endocrine system
https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2018.0072/47154

Further reading:

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
https://www.ncbi.nlm.nih.gov/pubmed/18844286

Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)
https://www.sciencedirect.com/science/article/abs/pii/S0731708517322367?via%3Dihub

Cannabis for the treatment of Crohn's disease
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012853.pub2/full