RAMSAY HUNT SYNDROME FOLLOWING COVID-19 VACCINATION - BRITISH MEDICAL JOURNAL

Postgraduate Medical Journal
Adverse drug reactions
Ramsay Hunt syndrome following COVID-19 vaccination
Chariene Jane Woo, Hou In Chou, Bernard Man Yung Cheung,
Correspondence to Professor Bernard Man Yung Cheung, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China;
http:// dx. doi. org/10.1136/postgradmedj-2021-141022

The COVID-19 pandemic has caused profound social and economic upheaval. COVID-19 vaccines promise to prevent infection of the SARS-CoV-2 virus. However, due to their expedited approval, these vaccines need to be vigilantly monitored for their safety. Cases of Bell’s palsy have also been reported after COVID-19 vaccine injection. In two phase III trials of COVID-19 vaccines involving around 38 000 patients, there were seven cases of Bell’s palsy after vaccine compared with one case after receiving placebo.1 2 As the p value was 0.07 and this was a post hoc analysis, no definite association could be inferred.

We recently diagnosed Ramsay Hunt syndrome (RHS) in a 37-year-old previously healthy man. Two days after his first dose of the Pfizer-BioNTech (BNT162b2) vaccine, he noticed fever and a pain in the right ear. Vesicles were then developed in his right ear and canal, together with vertigo, tinnitus and loss of hearing. He complained of facial palsy, tongue numbness and dysgeusia. On examination, he had grade 4 right facial nerve palsy of the lower motor neuron type with right sensorineural hearing loss (figure 1A). There were no other neurological deficits. Vesicles with serous discharge were found over the right concha and external auditory canal (figure 1B). A swab of the exudate was positive for varicella-zoster DNA on PCR, while throat saliva was negative for SARS-COV-2. A CT scan of the brain was normal. The diagnosis was RHS leading to peripheral facial nerve palsy, vestibulocochlear neuropathy and glossopharyngeal somatic sensory neuropathy. As his symptoms developed 2 days after vaccination, we suspected the vaccination triggered RHS. This would be the first reported case of RHS after COVID-19 vaccination.

Bell’s palsy is the most common cause of an acute onset peripheral facial palsy. Some cases were attributed to the reactivation of herpes-simplex virus (HSV) and varicella-zoster virus (VZV). The former is always underdiagnosed. However, the blisters of herpes zoster (HZ) allow a diagnosis to be made clinically. Reactivation of the VZV at the facial nerve leads to RHS type 2 (herpes-zoster oticus). However, there are also cases where RHS may manifest without the skin lesions such that it cannot be differentiated from Bell’s palsy without PCR or antibody titre testing.3

HZ is associated with COVID-19 vaccination. The US Vaccine Adverse Event Reporting System (VAERS) reported 232 HZ-related adverse events among COVID-19 vaccines among 1653 reports of vaccine-related complications since July 1990. All reported cases so far affected other dermatomes.4 VZV-specific CD8 cells may be temporarily incapable of controlling the VZV after the massive shift of naive CD8+ cells to produce vaccine-targeting CD8+ cells.4 The vaccine may also dampen the innate immunity responsible for controlling VZV.5 Therefore, vaccine-related immunomodulation may be responsible for the RHS after vaccination.

RHS is rare for patients under 60 years old with no previous history of HZ. Therefore, COVID-19 vaccination was likely to be the stress causing reactivation of VZV. What we have described is rare, and may be the missing link between COVID-19 vaccination and Bell’s palsy, providing a plausible explanation for the facial palsy.

https ://pmj. bmj. com/content/early/2022/01/05/postgradmedj-2021-141022

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