Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study)
https://pmj.bmj.com/content/early/2020/11/12/postgradmedj-2020-139065.full
It has been observed that vitamin D-deficient individuals
have increased COVID-19 risk and mortality
Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 2020;323:1824–36. doi: 10.1001/jama.2020.6019
The role of vitamin D in the prevention of coronavirus disease infection and mortality.
Aging Clin Exp Res 2020;32:1195–8. doi: 10.1007/s40520-020-01570-8
Association of vitamin D status and other clinical characteristics with COVID-19 test results.
JAMA Netw Open 2020;3:e2019722. (Published 3 Sep 2020).doi: 10.1001/jamanetworkopen.2020.19722
Immunomodulatory role and protective effect of vitamin D against other viral infections
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017;15:356:i6583. doi: 10.1136/bmj.i6583
An intervention study with calcifediol noticed a reduction in requirement for intensive care among hospitalised patients for COVID19
Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study.
J Steroid Biochem Mol Biol 2020;203:105751. doi: 10.1016/j.jsbmb.2020.105751
50 patients treated with calcifediol, one required admission to the ICU (2%), no deaths
26 untreated patients, 13 required admission (50 %) to the ICU, 2 deaths
Immune-modulatory effect of vitamin D is likely to be observed at 25(OH)D levels, which are considered higher than that required for its skeletal effects
Vitamin D to prevent COVID-19: recommendations for the design of clinical trials. Febs J2020;287:3689–92. doi: 10.1111/febs.15534
Positive correlation between circulating cathelicidin anti..
