Global Sepsis Alliance, Can COVID-19 cause sepsis
COVID-19 does indeed cause sepsis
Sepsis is “a life-threatening organ dysfunction caused by a dysregulated host response to infection.”
Other organs as well as the lungs
Direct viral invasion and sepsis
Seattle area in the United States, ICU patients
Septic shock severe enough to require drugs to support the heart and circulation in almost, 70%
Liver injury, over 30% had evidence of liver injury
Depressed immune response, 75%
Acute kidney failure, 20%
Significant heart damage, 28%
Potentially from direct invasion of cardiac muscle by the virus
Resulting in heart failure and abnormal heart rhythms
This cardiac damage was associated with a five-fold increase in the risk of death
COVID-19 causing sepsis
Critical Care Explorations (June, 2020)
Multisystemic clinical and autopsy findings
Viral sepsis accurately describes the whole clinical picture
Intense cytokine release
Immunosuppression with T cell exhaustion
Lymphopenia and immunosuppression
Optimal treatment uncertain
Supportive treatment and immunomodulators
Until effective antivirals are developed
UK Sepsis Trust
A life-threatening condition
When the body’s response to infection injures its own tissues and organs
A percentage of COVID-19 infections can result in such organ damage and subsequent failure
Therefore features in addition to respiratory failure
Sepsis associated with infection, any of the following
Slurred speech or confusion
Extreme shivering or muscle pain
Passing no urine (in a day)
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