Long-term Health Consequences of COVID-19
(JAMA, 5th October)
https://www.telegraph.co.uk/global-health/science-and-disease/long-covid-can-really-grim-rarer-think/
Ongoing symptoms to substantial end-organ dysfunction
https://jamanetwork.com/journals/jama/fullarticle/2771581?guestAccessKey=6c60fb00-1424-47b5-abc9-0b502a194f46&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=100520
Post-Acute COVID
Persistent severe symptoms, beyond 3 weeks
Chronic COVID-19
Beyond 12 weeks
Common complaints
https://www.bbc.co.uk/news/health-54296223
Crippling fatigue
Breathlessness
Persistent cough
Joint pain
Muscle aches
Chest pain
Hearing and eyesight problems
Headaches
Loss of smell and taste
Damage to the heart, lungs, kidneys and gut
Depression
Anxiety
Struggling to think clearly
Not directly related to severity of acute phase
Some cases may be related to pneumonia
Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19
https://pubmed.ncbi.nlm.nih.gov/32730238/
US CDC
Random sample of 292 adults who had tested positive
35% of 274 symptomatic respondents, not returned to usual health 14 – 16 days after testing
18 – 34 year olds
N = 85, 26%. (74% returned to normal)
35-49 years
N = 96, 32% (68% returned to normal)
50 and older
N = 89, 47% (53% returned to normal)
Post–intensive care syndrome
6 – 12 months, cognitive, mental health, physical function
Persistent Symptoms in Patients After Acute COVID-19 (JAMA, July 2020, Rome)
https://jamanetwork.com/journals/jama/fullarticle/2768351
143 patients discharged from the hospital
18 patients (12.6%) were completely free of any COVID-19–related symptoms after a mean of 60 days
Therefore 87.4 not returned to full normal
Manifestations
None of the patients had fever or any signs or symptoms of acute illness
Worsened quality of life, 44.1%
Pathogenesis
Direct tissue invasion by the virus
The virus ..
