First published at 07:28 UTC on October 27th, 2021.
Midazolam
In March 2020 the NHS purchased the equivalent of two years worth of supply. French suppliers were then given regulatory approval by the MHRA to sell additional stock to the NHS. This was then distributed for out of hospital use in the co…
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Midazolam
In March 2020 the NHS purchased the equivalent of two years worth of supply. French suppliers were then given regulatory approval by the MHRA to sell additional stock to the NHS. This was then distributed for out of hospital use in the community.
This benzodiazepine (midazolam) is a sedative/anaesthetic that suppresses respiration and the central nervous system (CNS). The British National Formula (BNF) recommends its use for sedation of anxious or agitated terminally ill patients using a mechanised syringe pump in doses of 30–200 micrograms/kg/hour. It is not recommended for conscious sedation in higher doses due to the following risks:
CNS (central nervous system) depression; compromised airway; severe respiratory depression.”
Therefore a frail, eight stone (50 kg) adult could receive an initial dose of up to 2.5mg followed by a total incremental dose of another 2.5mg over a 24hr period. The purpose of this would be to ease their anxiety and agitation if they were experiencing the frightening sensation of intense respiratory difficulty.
Midazolam becomes a conscious anaesthetic for use in intensive and palliative care when given in higher doses. The British Association for Palliative Medicine recommend:
Start with 2.5-5 milligrams – if necessary, increase progressively to 10 milligrams – maintain with 10-60 milligrams / 24h in a syringe pump”
DRLUKEEVANS MATTHANCOCK MIDAZOLAM
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