Do the COVID-19 mRNA vaccines reduce mortality? Seems no one is interested in answering this, certainly not the vaccine companies who produced vaccines that only dealt with symptom reduction.
Did they not think the studies should have dealt with mortality principally? Certainly not the experts in the EBM world for they would have never ever let the substandard sub-optimal Pfizer and Moderna so called RCTs, slip by without savaging them for the junk science they are. Especially the efforts to mislead with the relative risk reduction (RRR) estimates when the absolute risk reduction (ARR) was the estimate of effect most important. What about the 3400 or so participants excluded from one vaccine developer’s analysis?
Why has the EBM world sat silent, when as we showed, once we back calculate, the 95% RRR declines to 19%, not even reaching the 50% threshold for EAU. Something stinks to high heavens.
In another time, when money and grants was not the focus, the vanguards of the EBM world would have torn up these two corrupted mRNA studies and ran meta-analysis out of the wazoo and published in all the corrupted medical journals…they would have published repeatedly showing the failures for they love their meta-analysis…but that’s in another era, for the era of corrupted science, research grants for COVID bogus research etc. is the new dame in town and this is where all the love is…there is no more love flowing for proper science and proper RCTs methodologically and proper analysis.
Ah well, we will still try to take a look, while recognizing the underlying studies are corrupted and bogus to begin with. EBM world loves to pool, so we will pool for more power, to increase precision, and to arrive at a more robust pooled estimate of effect. Small number of events and small number of studies, in some sense weak sub-optimal methodology for both trials.
Bottom line: EBM is dead. Embarrassingly so.
mRNA vaccines pooled analysis:
Pfizer RCT: https://www.nejm.org/doi/suppl/10.1056/NEJMoa2110345/suppl_file/nejmoa2110345_appendix.pdf
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