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New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate
So, what is a protease?
So what is a protease inhibitor?
And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)
Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate
The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
https://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
https://www.nature.com/articles/s42003-020-01577-x
Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.
https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g
From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
https://www.nice.org.uk/bnf-uk-only
Ritonavir, C37H48N6O5S2
Ivermectin, C48H74O14
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate
Risk of virus developing resistance to PF-07321332
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full
