The Ghost in the Machine - 1967 book about philosophical psychology by Arthur Koestler.

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“Here at our disposal, to be used wisely or unwisely, is an increasing array of agents that manipulate human beings… It is now possible to act directly on the individual to modify his behaviour instead of, as in the past, indirectly through modification of the environment.” – Dean Saunders, of the San Francisco Medical School, at the Control of the Mind symposium (1961).*

The next quote was preceded by a discussion about the potential use of tricyano-aminopropene to cause an “increased suggestibility in man”.

“The author is [referring] to any substance inducing changes of biologically important molecules in the neurons and the glia and affecting the mental state in a negative direction. It is not difficult to imagine the possible uses to which a government in a police-controlled state could put this substance. For a time they would subject the population to hard conditions. Suddenly the hardship would be removed, and at the same time, the substance would be added to the tap water and the mass-communications media turned on. This method would be much cheaper, and would create more intriguing possibilities then [voluntary introduction methods]” – Hyden at the Control of the Mind symposium (1961).**
https://archive.org/details/TheGhostInTheMachine/page/n7/mode/2up
https://en.wikipedia.org/wiki/The_Ghost_in_the_Machine