Little House on the Prairie Season 8 Episode 20 A Faraway Cry
HydroxyChloroquine is a derivative of quinine
Little House On The Prairie Quinine Used for Influenza
So Quinine was used for influenza on Little House back in the 1800"s but now is a deadly for treating COVID
https://www.bitchute.com/video/NTGkd46qIri3/
Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477610/
Published online 2020 Sep 8
evidence that quinine exhibits antiviral activity against Sars-CoV-2 infection in Vitro
https://www.preprints.org/manuscript/202007.0102/v1/download
Received: 3 July 2020 / Approved: 6 July 2020 / Online: 6 July 2020
https://www.preprints.org/manuscript/202007.0102/v1
Quinine Inhibits Infection of Human Cell Lineswith SARS-CoV-2
https://www.mdpi.com/1999-4915/13/4/647/pdf
Received: 7 December 2020
Accepted: 1 April 2021
Published: 9 April 2021
Quinine: The Tonic for COVID-19?
https://www.pennmedicine.org/departments-and-centers/otorhinolaryngology/about-us/newsletters/latest-newsletter/quinine-the-tonic-for-covid19
Chloroquine is a derivative of quinine that has been widely used for decades as a form of treatment and prophylaxis against malaria.59 In addition to its antimalarial properties, chloroquine has shown broad-spectrum antiviral effects against a diverse range of viruses such as the dengue virus,60 Zika virus,61 chikungunya virus,62 and influenza viruses.63 It also proved to be an effective antiviral in vitro against SARS-CoV when introduced prior to or after the establishment of infection.45,64 More recently, it displayed similar potent antiviral effects against SARS-CoV-2, with an EC50 = 1 μM and CC50 > 100 μM.46
Quinine from Cinchona Bark: A potent bitter herb, misunderstood
https://medicinal-foods.com/quinine-cinchona-bark-potent-bitter-herb/
Cinchona bark is about 5% quinine, then 1 gram of the bark (1000mg x .05 = 50) would yield about 50mg of Quinine.
The broad-spectrum antiviral effects of chloroquine can be attributed to multiple potential mechanisms of action. Chloroquine is able to inhibit a pre-entry stage of SARS-CoV viral replication cycle by interfering with the binding of viral particles to their respective cellular surface receptors.65 Treatment with chloroquine has been shown to inhibit quinone reductase 2, an enzyme involved in the biosynthesis of sialic acids, which are acidic monosaccharides that are crucial components for ligand recognition.66 This inhibition subsequently resulted in a deficit in the glycosylation of ACE2, ultimately preventing viral binding and infection.64 Chloroquine is also able to interfere with another early stage of the virus replication cycle, namely the pH-dependent endosome-mediated entry of various enveloped viruses. The presence of chloroquine induces an elevation of the endosomal pH, thus preventing the fusion of viral envelope and the host endosomal membrane, a process that is usually mediated by acidification of the endosome.62 Given that the viral entry of CoVs into the host cell cytoplasm is also mediated by pH-dependent steps,67 this could well serve as another mechanism by which chloroquine inhibits CoV infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299369/
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Hydroxychloroquine, FrontLine Doctors, Drs Simone Gold,
Stella Immanuel, Harvy Riesch etc
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