Feline infectious peritonitis (FIP): how antiviral drug resistance really emerges

In this film for veterinary surgeons, I describe how antiviral drug resistance occurs in feline coronavirus infection: it is NOT due to early treatment, but instead it is due to treating with too low a dose of antiviral drug, and to using injections instead of pills. Pills get right to where the virus replicates: in the intestines, whereas injections may appear to heal feline infectious peritonitis temporarily, they predispose to a relapse, especially a neurological relapse if a low dose has permitted virus to persist in the brain.
Key messages:
1. do NOT use injections to treat FIP: use pills.
2. start treatment with a high dose of antiviral (exact dose will depend upon what you're using).

To download the 10 Rules to Prevent FIP relapses, or to make a donation to support films like this one, please visit my website: www.catvirus.com.
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Link to Dr Pedersen’s GS-441524 paper: https://journals.sagepub.com/doi/10.1177/1098612X19825701
Link to Dr Roy’s molnupiravir paper: www.mdpi.com/2076-0817/11/10/1209
Link to Dr Addie’s FIP treatment paper: www.mdpi.com/1999-4915/14/4/744

Disclaimer: please note that I (Diane Addie) have received no funding from Bova and WILL NOT take funding from them should they offer any in future, just as I refused an offer from Mutian: my patients come first, and it is important to me to not to have any conflicts of interest. Such independence is made possible by clients paying for their consultations, and most especially by the incredible generous and altruistic subscribers who keep food on my table: if you are one of my subscribers or donors then a HUGE THANK YOU TO YOU!