In the late 1950s and early 1960s, the use of thalidomide in pregnant women in 46 countries resulted in the "biggest man‐made medical disaster ever," with over 10,000 children born with a range of severe deformities, such as phocomelia, an…
In the late 1950s and early 1960s, the use of thalidomide in pregnant women in 46 countries resulted in the "biggest man‐made medical disaster ever," with over 10,000 children born with a range of severe deformities, such as phocomelia, and thousands of miscarriages.
Thalidomide was introduced in 1956 and was aggressively marketed by the German pharmaceutical company Chemie Grünenthal as a medication for anxiety, trouble sleeping, "tension", and morning sickness. It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. While initially deemed to be safe in pregnancy, concerns regarding birth defects were noted in 1961, and the medication was removed from the market in Europe that year.
Thalidomide was developed and first released by the German pharmaceutical company Chemie Grünenthal in 1953. The company had been established as a soap maker after World War II to address the urgent market need for antibiotics. Chemist Heinrich Mückter, who was a known Nazi war criminal, was appointed to head the discovery programme based on his experience researching and producing an anti-typhus vaccine for Nazi Germany.
The total number of people affected by the use of thalidomide during the mother's pregnancy is estimated at more than 10,000, of which approximately 40 percent died at or shortly after the time of birth. Those who survived had limb, eye, urinary tract, and heart defects.
The severity and location of the deformities depended on how many days into the pregnancy the mother was before beginning treatment; thalidomide taken on the 20th day of pregnancy caused central brain damage, day 21 would damage the eyes, day 22 the ears and face, day 24 the arms, and leg damage would occur if taken up to day 28. Thalidomide did not damage the fetus if taken after 42 days gestation.
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