***ANTI-PRION*** Bitchute censored!!!

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QUINACRINE- antiprion

https://www.biorxiv.org/content/10.1101/2021.04.19.440495v1.full

"Quinacrine, another tricyclic acridine derivative traditionally used as an anti-malaria drug and then identified as an anti-prion compound capable of directly binding to PrPC [92, 93].

These candidates were tested using ascending concentrations (0.1, 0.3, 1, and 3μM) for treatment (24h) in an established screening system using HEK293 cells stably expressing murine PrPC (Suppl. Fig. 6B; [94]). None of these compounds significantly altered levels of cell-associated PrPC. Likewise, no relevant changes for sPrP were detected with the surprising exception of Quinacrine, which rather caused a reduction in shedding. This could be due to its expected binding region at the C-terminus of PrPC (Suppl. Fig. 6A) overlapping with the cleavage site and, thus, potential hindrance of the protease. However, since we were rather interested in ligands increasing the shedding, we did not further investigate this aspect. Although we are continuing to screen for small compounds that stimulate shedding, the findings presented here may indicate that ligands of PrPC are required to exceed a critical size or fit certain sterical characteristics in order to stimulate its proteolytic shedding."