21st Century Adjuvant or 21st Century Final Solution

https://patents.google.com/patent/CA2166208C/en?q=Pcpp&oq=Pcpp

Coly's Toxin Adjuvant
Mineral Oil Adjuvant
Freund's Adjuvant
Aluminum hydroxide

The future of PETROLEUM!!!
Phosphazene polyelectrolytes as immunoadjuvants

Abstract
An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is a poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.

PHOSPHAZENE POLYELEGTROLYTES AS IMMUNOADJUVANTS
Background of the Invention This application is in the area of polymers for biomedical applications, and in particular describes polymers that can be used as immunoadjuvants.

Vaccine Development A wide variety of antigens stimulate the production of antibodies in animals and confer protection against subsequent infection. However, some antigens are unable to stimulate an effective immune response.
The immunogenicity of a relatively weak antigen is often enhanced by the simultaneous administration of the antigen with an adjuvant, a substance that is not immunogenic when administered alone, but will induce a state of mucosal and/or systemic immunity when combined with the antigen. It has been traditionally thought that adjuvants, such as mineral oil emulsions or aluminum hydroxide, form an antigen depot at the site of injection that slowly releases antigen.
Recent studies by Allison and Byars, in: "Vaccines: New Approaches to Immunological Problems:, R.W. Ellis, ed., p.
431, Butterworth-Heinemann, Oxford (1992) indicate that adjuvants enhance the immune response by stimulating specific and sometimes very narrow branches of the immune response by the release of cytokines.