The title quote is lifted from the end of this video.
The most caring and righteous are steamrolled by the most ruthless, conspiratorial, and cunning. You end up with a world controlled by malignant vampires over genetically and culturally engineered zombies. You want to blame the players instead of the reality Creator where karma is non-existent, evil thrives unimpeded, and innocence is punished. Jesus quotes Psalm 22:1, "My God, my God, why hast thou forsaken me?"
I know the evil laugh at and mock ideas of karma and God. That's because they know how much they get away with scot-free, particularly against the most well-meaning and righteous. They steal the joy of the unsuspecting innocent and triumph to celebrate their exploits.
Dostoevsky's The Idiot is about these ideas. Referencing the book, Nietzsche referred to Jesus as an idiot.